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Integrative Therapeutics Cortisol Manager Louise Hurst From the New York Times30 capsules From Emerson Ecologics website: The Stress Hormone Stabilizer Cortisol, often referred to as the stress hormone, is produced by the adrenal cortex in response to signals from the hypothalamus and pituitary gland, as part of the hypothalamic pituitary adrenal (HPA) axis. Cortisol is perhaps the most important hormone involved in the adaptation process. Upon exposure to acute stressors, cortisol secretion can generally help maintain